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Frontiers in Sports and Active Living

Frontiers Media SA

Preprints posted in the last 90 days, ranked by how well they match Frontiers in Sports and Active Living's content profile, based on 11 papers previously published here. The average preprint has a 0.01% match score for this journal, so anything above that is already an above-average fit.

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Injury epidemiology in HYROX athletes: an international cross-sectional survey

Ketzer, C. E.; Kirstein, L.; Bonleitner, M.; Beyerle, P.; Zehnder, P.; Schwarz, M.; Biberthaler, P.; Zyskowski, M.

2026-08-11 orthopedics 10.64898/2026.08.09.26359590 medRxiv
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Abstract Objective HYROX is a rapidly growing hybrid fitness competition combining running with functional exercise stations. Our objective was to describe the 12-month prevalence, characteristics and severity of self-reported HYROX-related injuries. Methods We conducted an international cross-sectional online survey of 418 HYROX athletes. The primary outcome was the self-reported 12-month period prevalence of at least one HYROX-related injury; secondary outcomes included an exposure-adjusted lower-bound rate per 1000 hours of total training exposure and the profile and severity of the most significant injury. Associated factors were examined by multivariable logistic regression. Results Overall, 208 of 418 participants (49.8%, 95% CI 45.0 to 54.5) reported at least one HYROX-related injury. The exposure-adjusted lower-bound rate was 1.65 reported injuries per 1000 hours of total training exposure. Injuries mainly affected the lower extremity, most commonly the knee (20.8%); tendon-related complaints were the leading type (41.6%) and most were of gradual onset. Among participants with severity data, 20.3% reported more than 28 days of training interruption or no return to their previous performance level. Higher HYROX-specific training frequency was the only factor independently associated with injury reporting (adjusted OR 1.61, 95% CI 1.20 to 2.16; p = 0.001). Conclusion Approximately half of respondents reported at least one HYROX-related injury during the preceding 12 months, predominantly involving gradual-onset lower-extremity complaints. Higher HYROX-specific training frequency was associated with injury reporting, although the cross-sectional design precludes causal interpretation. Prospective, exposure-based surveillance is needed to quantify HYROX-specific injury incidence and burden and examine whether training frequency, load distribution and recovery contribute to injury risk.

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Relative reliability, construct validity, and concurrent validity of the Jiu-Jitsu Anaerobic Performance Test (JJAPT)

Soares, F. A. F.; Andreato, L. V.; Machado, H. E. d. S.; Coswig, V. S.; Lima, A. A. M.

2026-06-29 sports medicine 10.64898/2026.06.24.26356347 medRxiv
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This study aimed to investigate the test-retest reliability of the Jiu-Jitsu Anaerobic Performance Test (JJAPT), as well as its construct validity according to experience level (intermediate and advanced) and belt rank (blue, purple, brown, and black), in addition to its concurrent validity with physical performance measures. Twenty-three amateur Brazilian Jiu-Jitsu (BJJ) athletes participated in two assessment sessions. JJAPT repetitions (mean, peak, and total) were analyzed under 4 and 5-set protocols, along with physical tests including vertical jump, Wingate test, and specific strength-endurance tests. Reliability was assessed using the intraclass correlation coefficient (ICC), construct validity through t-tests and ANOVA, and concurrent validity through Pearsons correlation. Results indicated that the JJAPT showed moderate to good reliability (ICC = 0.74 to 0.82). No significant differences were observed between experience levels or belt ranks for any variables (p > 0.05), with trivial effect sizes, indicating a lack of discriminant validity. On the other hand, significant correlations were found between JJAPT performance and isometric and dynamic strength-endurance tests (r = 0.39 to 0.62), with moderate to large magnitudes. It is concluded that the JJAPT shows measurement stability; however, it demonstrates limited ability to discriminate performance between athletes of different experience levels and belt ranks, being more strongly associated with strength-endurance capacities. Keywords: Brazilian Jiu-Jitsu; anaerobic performance; training monitoring

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Understanding the biomechanical and physiological responses to Advanced Footwear Technology in well-trained male and female runners

Albertus, Y.; Leith, D.; Berg, O.; Barrons, Z. B.; Tam, N.

2026-06-24 physiology 10.64898/2026.06.19.732297 medRxiv
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Advanced footwear technology (AFT) has transformed competitive running, yet individual and sex-specific responses to different AFT models remain unclear, particularly near race pace. This study examined running economy (RE) and gait biomechanics in response to three top-tier AFT models (Shoe A: adidas Pro Evo 2; Shoe B: Nike Alphafly 3; Shoe C: On CloudBoom Strike 2) in 14 male and 12 female well-trained runners at sex-specific submaximal speeds (16 and 14 km{middle dot}h-{superscript 1}). RE, spatiotemporal, and joint kinematic/kinetic data were collected via indirect calorimetry, accelerometry, and three-dimensional motion capture with force platforms. RE was significantly lower in Shoe C than Shoe A (males: 2.1%; females: 1.4%) and Shoe B (males: 1.9%; females: 0.9%), with 73% of runners responding favourably to Shoe C, a more consistent response than previously reported. Despite being lightest, Shoe A produced the poorest RE, challenging conventional mass-economy assumptions. Biomechanically, Shoe C elicited greater impact magnitude, lower ankle quasi-stiffness, and greater ankle angular velocity during early stance. Female runners showed smaller RE improvements, potentially related to lower running velocity and body mass limiting midsole engagement. The most efficient AFT enabled these well-trained runners to be more spring-like through tolerating higher forces and faster angular velocities without greater demand on metabolic cost.

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Predictors of Brain Injury: The Performance of Biomechanical Head Acceleration Severity Metrics for Concussion Prediction in Men's and Women's Rugby League Players

Tooby, J.; Owen, C.; Whitehead, S.; Scantlebury, S.; Vishnubala, D.; Wu, L.; Kitchin, M.; Ji, S.; Rowson, S.; Tucker, R.; Zhang, C.; Jones, B.

2026-08-13 sports medicine 10.64898/2026.08.12.26360260 medRxiv
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ObjectiveDescribe and compare the biomechanical severity of head acceleration events (HAEs) associated with diagnosed concussion in elite mens and womens rugby league using instrumented mouthguards (iMGs) and evaluate the diagnostic accuracy and screening performance of severity metrics within the current Head Injury Assessment (HIA) process. MethodsA prospective cohort of 398 men and 252 women from Super League teams wore iMGs across 515 matches. Following a matching and data quality screening procedure, 123 HIAs (106 men, 17 women) were matched to HAEs, 52 of which were diagnosed concussions (44 men, 8 women). High-magnitude asymptomatic control HAEs (22,676 men, 3,200 women) were sampled proportionally to the number of HIAs. A range of biomechanical severity metrics were calculated for HAEs. Statistical comparisons between outcomes were made. Receiver operating characteristic (ROC) analysis evaluated diagnostic accuracy (ability to predict diagnosed concussions within the HIA). Precision-recall analysis evaluated screening performance (ability to discriminate observable concussion signs from asymptomatic events). ResultsDiagnosed concussions had greater severity than asymptomatic HAEs across all metrics in both sexes. For diagnostic accuracy, area under the ROC curve ranged from 0.61 to 0.72 in men and 0.53 to 0.86 in women. For screening performance, optimal thresholds in several metrics provided theoretical improvements to precision over current thresholds used in rugby, but recall remained <0.20. ConclusionThese findings support integrating iMG-derived severity metrics into a multimodal, clinician-led HIA pathway as objective adjuncts for diagnosis and screening, while reinforcing that they cannot replace clinical judgement or other assessment modalities. What is already known on this topicInstrumented mouthguards are increasingly used in rugby to quantify head acceleration events and trigger Head Injury Assessment (HIA) alerts, but current screening thresholds based on simple peak kinematics have low sensitivity for identifying HAEs linked with visible concussion signs, and very few iMG-measured concussions, particularly in women, have been reported in current research. What this study addsThis study provides the largest dataset of iMG-measured concussions in any sport, shows that concussive HAEs are more severe than asymptomatic events across multiple biomechanical metrics in both sexes, and identifies several severity metrics with diagnostic accuracy comparable to existing HIA sub-tests and modest theoretical improvements over current screening thresholds. How this study might affect research, practice or policyThese findings support incorporating iMG-derived severity metrics as objective adjuncts within clinician-led HIA pathways, highlight the need for sex-inclusive iMG datasets and multimodal concussion identification, and may inform future refinement of iMG screening thresholds in elite rugby and other contact sports.

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Slider Horizontal Movement and Arm Angle are Associated with Elbow and Forearm Injury Incidence in MLB Pitchers

Richards, C.; La Salle, D. T.; Vila Dieguez, O.; Ward, S. R.

2026-08-31 sports medicine 10.64898/2026.08.30.26361739 medRxiv
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Background: Sweeping sliders with large horizontal break are hypothesized to be associated with arm injury, and prior work suggests a link between slider usage, arm angle, and injury. Purpose: To evaluate whether arm angle and slider horizontal movement are associated with elbow or forearm injury risk in MLB pitchers. Study Design: Retrospective cohort study; Level of evidence, 3 Methods: Statcast data from 2020-2025 and injury data were used to study the relationship between sliders and arm injuries. Pitchers with at least 30 innings pitched (IP) were evaluated for same- and next-season injury incidence to the Elbow, Forearm, or Elbow/Forearm. A generalized additive model (GAM) related pitch-level variables to injury incidence, and average marginal effect (AME) odds ratios are reported for main effects. Results: All fits were significant at p<.01. Fits for same-season (N=1,957, p=.00008, R2=.066) and next-season (N=2,511, p=.00005, R2=.053) Elbow/Forearm injury were significant at p<.001. Same-season (R2=.061) and next-season (R2=.055) Forearm injury fits had p=.001. Main effects for slider glove-side movement and fastball usage, their interactions with arm angle, and arm angle main effects were the most predictive features. Across the three fits where the slider glove-side movement main effect was significant, odds ratios ranged from 1.03 to 1.07, meaning that each additional inch of slider glove-side movement was associated with a 3% to 7% increase in the observed injury incidence. Furthermore, this effect was magnified at high arm angle and muted at low arm angle. Conclusion: We observed that slider horizontal movement, arm angle, and their interaction were significantly associated with incidence of Forearm and combined Elbow/Forearm injury. This effect was weak or non-existent at low arm angles and strong at high arm angles, suggesting that arm angle moderates the risk of slider horizontal movement, and providing evidence that sliders with large horizontal break (e.g. sweepers) may pose an injury risk. Keywords: baseball; sweeper; slider; arm angle; horizontal movement; elbow injury; forearm injury

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Feasibility study of gait analysis using a new Wearable Force Plate

Sanz Morere, C. B.; Garrido-Lopez, G.; Hayase, M.; Rueda, J.; An, Q.; Shimoda, S.; Moreno, J. C.; Navarro, E.

2026-09-02 rehabilitation medicine and physical therapy 10.64898/2026.08.30.26361786 medRxiv
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Static force plates (FP) are the gold standard for measuring ground reaction forces (GRF) and computing joint moments through inverse dynamics in gait analysis. However, they are restricted to controlled environments, and the number of steps analyzed is limited by the plates embedded in the floor. To address these limitations, portable solutions such as sensorized insoles, socks, or shoes have emerged. Yet, creating wearable systems capable of measuring three-dimensional GRF in real-world conditions remains challenging. Current sensorized shoes often incorporate thick sensors (up to 2 cm), reducing usability and limiting their application in pathological populations or dynamic tasks like running. This study evaluates the usability of ShokacShoes, a novel sensorized shoe integrating three thin, three-dimensional force sensors, and explores its potential as a Wearable Force Plate (WFP). Eight healthy participants performed slow, natural, and fast walking using two insole configurations. Force and temporal metrics were derived from WFP and FP data. Results indicate that WFP enables accurate step segmentation and detects significant effects of speed and insole type on temporal and force metrics, confirming its reliability under different walking conditions. Comparisons with FP revealed differences in force metrics and signal morphology, though temporal parameters remained consistent. These results are likely due to sensor quantity and positioning. Thereby, ShokacShoes represent a valid solution capable of measuring three-dimensional forces within commercial footwear. Future work will focus on validating the applicability of a new version of ShokacShoes against gold-standard FP in a comprehensive validation study involving diverse real-world scenarios and pathological conditions.

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The effects of force constraint during preparatory phase on the explosive force generation of base stealing in baseball.

Konno, K.; Itaya, A.; Kizuka, T.; Ono, S.

2026-06-12 neuroscience 10.64898/2026.06.10.731238 medRxiv
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BackgroundExplosive force generation during the initial acceleration phase is critical for successful base stealing in baseball. Preparatory balance control preceding movement onset may facilitate this process by constraining horizontal ground reaction force (GRF) toward a task-specific direction. However, its contribution to ballistic sprint initiation remains unclear. Research questionDoes preparatory force constraint influence explosive force generation during base stealing, and when during the preparatory phase is this influence greatest? MethodsFourteen baseball players performed 3-m maximal sprints simulating base stealing under time-constraint (Time) and self-paced (Self) conditions. GRF around movement onset were recorded. Peak rate of force development (peak RFD) was computed from onset to take-off. A 250-ms window before the onset was divided into 50-ms bins, and mean resultant length (Rlen), which represents the extent of force constraint, of each bin was calculated. Using statistics analyses, Differences between conditions were tested, and the relationship between the interaction (Rlen x condition) and peak RFD was assessed. ResultsThe peak RFD was greater under the Self condition than under the Time condition, accompanied by a larger Rlen. Furthermore, Results indicated that the force constraint in the 150-100 ms interval preceding the movement onset most strongly influenced the peak RFD. SignificanceThese findings demonstrate that temporally organized preparatory force constraint plays a critical role in explosive sprint initiation during base stealing. Identifying the specific preparatory timing linked to superior force production provides novel mechanistic insight into preparatory balance control and may inform targeted training strategies for ballistic athletic movements.

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Arm Angle Moderates the Association Between Fastball Usage and Elbow/Forearm Injury in MLB Pitchers

Richards, C.; La Salle, D. T.; Vila Dieguez, O.; Ward, S. R.

2026-08-31 sports medicine 10.64898/2026.08.29.26361727 medRxiv
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Background: Newly available arm angle data offers a new dimension to understand rising rates of arm injury in MLB pitchers. Purpose: To evaluate the relationship between arm angle, pitch characteristics, and elbow and forearm injury in MLB pitchers.<br><br> Study Design: Retrospective cohort study; Level of evidence, 3 Methods: Statcast data from 2020 to 2025 and MLB injured list (IL) data were used to evaluate arm angle and pitch characteristics in relation to elbow and forearm injuries. Results are presented with and without requirements on prior season workload and for same-season and next-season injury incidence. A generalized additive model (GAM) was used to capture non-linear dependence and interactions between selected features and injury incidence to the elbow or forearm. Average marginal effect (AME) odds ratios are reported for main effect terms. Results: N = 3,812 pitcher-seasons were included. 29% pitchers who underwent UCLR did so in the same season as a forearm injury (tmean=44, tmedian=27 days to surgery). Arm angle, fastball usage, and their interaction were the three most predictive features. Arm angle was positively related to incidence of injury (ORmeanAME=1.014), fastball usage was inversely related to incidence of injury (ORmeanAME=0.243), and arm angle moderated the effect fastball usage at high arm angle, where increased usage was no longer protective. Slider velocity (ORmeanAME=1.072), spin rate (ORmeanAME=1.001), and usage (ORmeanAME=2.039) also significantly predicted injury risk. Fastball velocity was not significant in any fit, with ORmeanAME=0.999 across all fits. Fit-level Nagelkerke R2 values ranged from .019 to .052. Conclusion: Fastball usage and arm angle, not velocity, predicted elbow and forearm injury risk among MLB pitchers, and arm angle was the single most predictive feature. The heterogeneity of risk factors as a function of arm angle, and the novelty of MLB arm angle data, may explain why fastball usage has been previously underexplored as a risk factor. Keywords: baseball; arm angle; fastball velocity; fastball usage; spin rate; UCL; ulnar collateral ligament; elbow injury; forearm injury; Statcast

9
Chronic adaptations following eccentric cycling training at different cadences

Mater, A.; Martin, A.; Laroche, D.; Lepers, R.

2026-07-10 sports medicine 10.64898/2026.07.07.26356024 medRxiv
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Pedalling cadence during an acute eccentric cycling exercise altered physiological and perceptual responses. We examined the influence of cycling cadence on neuromuscular adaptation induced by a 6-week eccentric cycling training period. Eighteen participants performed training (eighteen sessions) at a cadence of 30 or 60 rpm over six weeks. Power output was the same between the two groups. Perceived effort and heart rate were recorded at each training session. Muscle pain and fatigue were reported the day after each session. Maximal voluntary contractions torque, as well as concentric and eccentric cycling efficiency, were assessed before and after training. Additionally, the loss of maximal voluntary isometric torque was assessed after the first and last training sessions. Heart rate and perceived effort increased in the second week of training and then plateaued, with no difference between groups. Muscle pain and fatigue remained low throughout the training, with no difference between groups. Isometric (+28%) and eccentric (+13%) maximal voluntary torque of knee extensor muscles increased regardless of training cadence. Concentric maximal voluntary torque increased for the group pedalling at 60 rpm only (+21%). Cycling efficiency was improved in eccentric mode only (+43%), with no difference between the two training groups. Finally, the voluntary isometric torque loss induced by the first and last sessions were similar. While six weeks of eccentric cycling training improved neuromuscular and functional capacities, cadence had no observable effect. This finding suggest that patients could choose their preferred cadence to obtain better adherence to the rehabilitation program without altering the adaptations.

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Progressive plyometric training improves jumping performance and reduces force-velocity imbalance in collegiate volleyball players

Wu, H.; Xi, X.; Li, J.

2026-07-30 physiology 10.64898/2026.07.22.740194 medRxiv
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Few studies have focused on plyometric interventions lasting over 24 weeks in team-sport athletes, and little research has validated the practical utility of personalized force-velocity assessment. A total of 36 university volleyball athletes (21.35{+/-}1.87 years) were randomly allocated into either a 32-week plyometric training group (PT, n=18) or a low-intensity active control group (CON, n=18); 34 players completed the trial (17 per group). PT completed three weekly training sessions, while CON maintained routine technical practice and general low-intensity conditioning. CMJ height, RSImod, and force-velocity profiles (F, V, peak power, FV imbalance) were evaluated at baseline and at weeks 8, 16, 24, and 32. PT increased CMJ height from 33.1{+/-}4.8 cm to 38.4{+/-}5.2 cm, a net gain of 5.3 cm (p<0.01, d=0.99, 95% CI [0.57, 1.41]); CON showed negligible change (+0.5 cm, p=0.68). The PT group also improved RSImod by 31.6% (d=0.87, 95% CI [0.45, 1.29], p<0.01) and peak power by 18.4% (d=0.76, 95% CI [0.35, 1.17], p=0.004). Meanwhile, FV imbalance dropped markedly by 31.4%, from 28.3% to 19.4% (d=-0.68, 95% CI [-1.09, -0.27], p=0.024). No significant F-V changes occurred in CON. The reduction in FV imbalance correlated moderately with CMJ gain (r= - 0.53, p=0.024), whereas the change in peak power did not (r=0.21, p=0.39). Overall, 32 weeks of periodized plyometric training enhanced jump performance, reactive strength, and power, and reduced the force-velocity (FV) imbalance by approximately 31%. The magnitude of improvements in jump performance (16%) and FV imbalance reduction (31%) observed in this 32-week periodized program fall within a similar range to previously reported effects of individualized F-V training (14% and 40%, respectively). However, direct numerical comparisons are confounded by differences in study design, population, and methodology; head-to-head trials are needed.

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Bench-stepping training improves stair-walking dynamics in older women: evidence from an exploratory nonlinear kinematic analysis

Baggen, R. J.; van Schooten, K. S.; Van Roie, E.; Verschueren, S. M.; Delecluse, C.; Delbaere, K.; Lord, S. R.; van Dieen, J. H.

2026-07-07 sports medicine 10.64898/2026.07.02.26357116 medRxiv
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Introduction: Stair walking challenges balance and coordination in older people. Bench-stepping training improves stair climbing speed in healthy older women. This study assessed whether bench-stepping also improves dynamic balance and movement complexity during stair walking. Methods: Stair walking data were obtained from a previous study involving 45 healthy older women (69y+/-4) that assessed the effects of a 12-week bench-stepping intervention with non-training controls. Centre-of-mass acceleration was measured during stair ascent and descent. Linear dynamics included time, acceleration magnitude, and harmonic ratios (HR; indicating symmetry). Movement complexity was quantified using nonlinear dynamics including sample entropy (SE), recurrence quantification analysis (RQA), and fractal dimension (FD). Results: For stair ascent, increased speed (p =0.018, R2partial =0.093,) was accompanied by proportional increases in acceleration magnitudes (p=<0.039, R2partial =0.078-0.101). SE decreased more in the intervention group (p=<0.012, R2partial =0.049-0.101), indicating more predictable dynamics. In contrast, for stair descent, no changes in speed or acceleration magnitudes were observed. However, SE (p =0.001, R2partial =0.082) and maximum RQA line length (p= 0.008, R2partial =0.057) of vertical acceleration increased significantly compared to controls, indicating lower predictability and more persistent recurring patterns. No significant changes were found for other outcomes. Exploratory factor analysis revealed distinct differences in motor behaviour between stair ascent and descent. Conclusion: Bench-stepping training induced measurable changes in stair walking dynamics. Specifically, sample entropy shows potential as a sensitive marker of altered motor complexity, particularly of vertical accelerations. Interestingly, the direction of changes in unpredictability differed between stair ascent and descent, suggesting different underlying control strategies.

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Muscle stability deficits are strongly associated with musculoskeletal complaints in football (soccer) players: the AF-Ratio outperforms conventional strength parameters--a cross-sectional study with preliminary follow-up

Schaefer, L. V.; Bittmann, F. N.; Ulrich, J.; Prill, R.; Becker, R.

2026-07-10 sports medicine 10.64898/2026.07.07.26357205 medRxiv
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Objectives: Given the high injury burden in football and the documented limitations of strength-based screening, novel approaches are warranted. Adaptive Force (AF)being closer to injury-prone movements than pushing/pulling strength--offers an alternative. This study examined the association between AF-based muscle stability and musculoskeletal complaints in football players and compared AF-derived and conventional strength parameters in their discriminative capacity, complemented by a preliminary prospective follow-up. Methods: AF and maximal voluntary isometric contraction (MVIC) were measured in 23 male football players across five bilateral muscle groups (knee extensors/flexors; hip flexors/adductors/abductors). AF parameters (maximal isometric AF, maximal AF, AF-Ratio), MVIC and hamstrings-to-quadriceps (H:Q) ratio were compared between players with and without complaints assessed via questionnaire at baseline and six-month follow-up (n=13). Results: Stability deficits were strongly associated with complaints (OR=54.0, 82% side concordance). AF-Ratio discriminated clearly between players with and without complaints (d=-1.47), with hip abductors showing the strongest effect (d=-1.64). Players with subsequent complaints showed lower baseline AF-Ratio (d=-1.45) and more stability deficits (d=1.67). MVIC and H:Q ratio did not discriminate (p>0.430). Conclusion: The findings suggest that muscle stability assessment outperforms conventional strength parameters in discriminating players with and without complaints, with preliminary follow-up data providing tentative support for predictive value. The concept of functional instability syndrome (FIS) provides a mechanistic framework for non-contact injuries and musculoskeletal complaints. AF assessment offers potential for screening, including return-to-sport decisions. Further studies are needed to verify the results, investigate predictive value, and evaluate whether personalised stability-based interventions can reduce injury incidence.

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Effect of Match-Play Fatigue on Muscle Stiffness and Explosive Force Asymmetries in Soccer Players Post-Anterior Cruciate Ligament Reconstruction

Bari, M. H.; Bhalli, A. Z.; Sattar, H.

2026-07-21 sports medicine 10.64898/2026.07.18.26357476 medRxiv
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ABSTRACT Background: Athletes who return to soccer after anterior cruciate ligament reconstruction (ACLR) remain at elevated risk of secondary injury despite meeting conventional discharge criteria, and neuromuscular deficits in the reconstructed limb are known to be exposed by fatigue. Objective: To determine whether match-play fatigue differentially affects muscle stiffness, countermovement jump (CMJ) force symmetry, and rate of force development (RFD) asymmetry between soccer players with a history of ACLR and uninjured teammates. Methods: A prospective, cross-sectional, matched-control study enrolled 128 competitive soccer players (64 ACLR, 6-22 months post-surgery; 64 uninjured controls) across five recruitment waves (February-June 2026). Bilateral CMJ peak vertical force, jump height, RFD, and myotonometric stiffness of the rectus femoris (RF), vastus medialis (VM), and biceps femoris (BF) were recorded immediately before and after a standardized competitive match. Fatigue was quantified from second-half heart rate (percentage of age-predicted maximum) and end-match rating of perceived exertion (RPE). Within-group pre-to-post changes were evaluated with paired t-tests, between-group differences in the magnitude of change with independent-samples t-tests, and associations between fatigue indices and asymmetry changes with Pearson correlations. Results: Match play reduced CMJ limb symmetry index (LSI) in both groups, but the decline was more than three-fold greater in the ACLR group, 92.6% (SD 5.4%) to 85.1% (SD 7.1%), than in control group, 97.3% (SD 3.9%) to 95.0% (SD 4.2%), group-by-time difference, p < 0.001, (d = 0.64). RFD asymmetry approximately doubled in the ACLR group, 10.6% (SD 4.1%) to 17.6% (SD 6.5%), compared with a smaller rise in control group, 4.6% (SD 2.4%) to 6.3% (SD 3.7%); p < 0.001, d = 0.77). Involved-limb stiffness losses in the ACLR group exceeded those of controls for the RF (-21.2 vs. -9.2 N/m, p < 0.001), VM (-17.7 vs. -6.1 N/m, p < 0.001), and BF (-13.3 vs. -6.6 N/m, p < 0.001), whereas uninvolved-limb stiffness losses did not differ between groups (all p > 0.05). Fatigue markers (heart rate, RPE) were not significantly correlated with the magnitude of individual asymmetry change (|r| [&le;] 0.18, p > 0.15). Conclusions: In competitive soccer players 6-22 months after ACLR, match-play fatigue selectively compromises stiffness and explosive force output of the reconstructed limb, widening inter-limb asymmetries beyond what is seen in uninjured teammates, even though global cardiovascular and perceptual fatigue were comparable between groups. These findings suggest that return-to-sport testing performed only in a rested state may underestimate residual neuromuscular deficits, and support fatigue-inclusive assessment protocols before athletes are cleared for unrestricted competition. Abbreviations: ACL: anterior cruciate ligament, ACLR: anterior cruciate ligament reconstruction, BF: biceps femoris, CMJ: countermovement jump, HRmax: maximum heart rate, LSI: limb symmetry index, RF: rectus femoris, RFD: rate of force development, RPE: rating of perceived exertion, RTS: return to sport, VM: vastus medialis, SD: standard deviation. Keywords: Anterior cruciate ligament reconstruction, muscle fatigue, muscle stiffness, countermovement jump, limb symmetry index, rate of force development, soccer, return to sport.

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Integrating mouthguard kinematics, finite element brain strain, and plasma biomarkers to explore brain injury thresholds in collision sport

Hickey, J. W.; Chan, E. Y. K.; Evans, L. J.; O'Brien, W. T.; Xie, B.; Roberts, S. S. H.; Butler, S. E.; Ernst, J.; Zhou, W. J. Q.; Zimmerman, K. A.; Spitz, G.; Parker, T. D.; O'Brien, T. J.; Shultz, S. R.; Sharp, D. J.; Ghajari, M.; McDonald, S. J.

2026-08-31 sports medicine 10.64898/2026.08.26.26360869 medRxiv
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Purpose: Identifying head impacts linked to brain injury in sport remains challenging. Instrumented mouthguards quantify head-impact kinematics, and finite element (FE) modelling can transform these data into brain strain estimates, which may better reflect injury risk than kinematics alone. Here, we examined associations between mouthguard-measured kinematics, FE-derived strain, and plasma brain injury biomarker GFAP following head impacts. Methods: We analysed 41 video-verified impacts from male Australian football players, including 22 assessed for concussion (17 diagnosed) and 19 unassessed. Instrumented mouthguards recorded peak linear acceleration (PLA), peak rotational acceleration, and peak rotational velocity (PRV). Brain strain was estimated using the Imperial College FE brain model, and plasma GFAP was quantified using Simoa. Biomechanical-GFAP associations were examined using Spearman correlations and segmented regression. Results: For impacts overall, plasma GFAP was moderately correlated with PLA ({rho}=0.46, 95% CI: 0.20-0.66), PRV ({rho}=0.53, 95% CI: 0.20-0.78), and strain ({rho}=0.60, 95% CI: 0.32-0.80). Associations were stronger within concussion cases for strain ({rho}=0.86, 95% CI: 0.58-0.97) and PRV ({rho}=0.64, 95% CI: 0.15-0.93). Piecewise regression identified strain levels above which strain-GFAP relationships steepened across the whole-brain and brainstem. In concussion cases, supra-threshold brainstem strain was associated with greater symptoms. Conclusion: Finite element brain strain may better predict brain injury risk following a sport-related head impact than peak acceleration metrics. Stronger associations with plasma GFAP, particularly among concussion cases, and evidence of a biomechanical threshold, support the use of biomarker-informed strain measures in future risk modelling and the development of brain injury screening thresholds.

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Understanding how demographic characteristics impact the level of physical activity children with neuromotor impairments experience while using a robot-assisted walker

Youngblood, J. L.; Zaplachinski, M.; Shen, H.; Condliffe, E. G.

2026-08-25 rehabilitation medicine and physical therapy 10.64898/2026.08.21.26361070 medRxiv
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Importance: There are very few interventions designed for individuals with the most severe mobility impairments. Robotic walking may be an effective way to facilitate exercise in this population. Objective: To examine how robot-assisted walkers physical parameters and user characteristics moderate the exercise intensity achieved by individuals with neuromotor disorders causing mobility impairments. Design: A prospective study. Intervention: A single-session intervention involving an overground robot-assisted walker that can be used in an endurance mode requiring no voluntary movement or a strength mode during which voluntary movement could impact the gait pattern. Participants: Individuals with pediatric-onset mobility impairments Main Outcome Measures: Participants were characterized based on their age, sex, diagnosis, and Gilette Functional Assessment Questionnaire (FAQ) levels. Heart rate during the final minute of four 5-minute walking conditions: strength mode at fast speed, strength mode at slow speed, endurance mode at fast speed and endurance mode at slow speed was expressed as a percentage of each participant heart rate reserve (%HRR). Linear mixed-effects models were used to evaluate the impact of speed, device mode and user characteristics on the level of exercise achieved. Results: 29 individuals (aged 2-26 years) with mobility impairments (FAQ levels 1-6) completed this study. Fast speeds were associated with a higher %HRR (beta= 2.11, SE = 1.03, p = 0.044). Participants in FAQ class 1 exhibited significantly higher %HRR compared with those in FAQ classes 2 and 3 (beta=18.6, SE=7.31, p=0.017; beta= 16.9, SE = 8.13, p = 0.047, respectively). No other device or participant characteristics were associated with exercise intensity. Conclusions: To facilitate higher exercise levels, users of robot-assisted walkers can increase their speed. Individuals who cannot take steps due to their neuromotor impairments experience the highest levels of exercise. Relevance: The findings in this study highlight the promise of robot-assisted walkers to improve health, particularly in those who often face the greatest barriers to exercise.

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Safe attitudes, uncertain implementation: concussion knowledge, attitudes, and confidence among parents and staff in junior community Australian football.

Bennett, H.; Fletcher, C.; Jemson-Ledger, E.; Garrett, J.

2026-07-22 sports medicine 10.64898/2026.07.20.26358513 medRxiv
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Introduction: Parents and club staff are primarily responsible for recognising and managing concussion in junior community Australian Football (ARF), yet no recent research has examined their knowledge or practices. This study assessed concussion knowledge, attitudes, and confidence among parents and staff in junior (under-16 years) community ARF, and identified management practices and perceived barriers. Methods: An online survey assessing concussion knowledge and attitudes (RoCKAS-ST), confidence, and AFL-specific guideline knowledge was distributed nationally to parents and staff of junior community ARF players. A subsample whose child had a concussion in the previous 12 months completed additional questions on management practices. Closed-ended responses were analysed descriptively and using Pearsons correlation. Open-ended responses underwent qualitative content analysis. Results: Responses (n=223) reflected high general concussion knowledge (76.6% of maximum) and positive attitudes toward safe concussion management (86.8% of maximum), but AFL-specific guideline knowledge was limited (49.8%). Self-reported confidence was not associated with knowledge (r = -0.04) or attitudes (r = .09). Among 58 respondents whose child recently sustained a concussion, medical evaluation (74.1%) and clearance prior to return (60.3%) were common, but graded return-to-play protocol use (50.0%) and club support during recovery (43.1%) were inconsistent. Knowledge gaps (70.4%), cultural attitudes favouring playing through symptoms (29.6%), and inadequate volunteer capacity (29.6%) were most common barriers. Conclusions: Parents and staff in junior community ARF hold safe attitudes toward concussion but lack the sport-specific knowledge, structural support, and resources to translate these attitudes into practice. Targeted, mandated education, and improved support are needed to close this gap.

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Supershoes or Superhumans? A controlled analysis of sex-specific road-running performance evolution in the era of advanced footwear technology

Blattmann, L.; Hamacher, D.; Tucker, R.; Healey, L.; Mason, J.

2026-07-03 physiology 10.64898/2026.07.03.736031 medRxiv
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Advanced footwear technology (AFT) improves running economy and is widely credited with recent performance improvements in road running, with observational analyses consistently demonstrating that women have improved more than men. In contrast, laboratory studies generally report similar running economy responses to AFT in both sexes, leaving the observational-experimental divergence unresolved. A fundamental limitation of observational work is the absence of a control condition, making it impossible to separate AFT-related gains from concurrent performance trends. We addressed this by comparing performances between pre-AFT (2009-2015) and AFT (2017-2024) eras across road-running events (10km, half marathon, marathon) and throwing events (shot put, discus, javelin, hammer), the latter serving as an active control condition subject to the same broad athletic trends but unaffected by footwear technology. The top 50 performances per event, era, and sex were converted to World Athletics points and analysed using linear mixed-effects models. Performances improved significantly between eras ({beta} = 0.294, p < .001), with gains substantially larger in road running than in throwing ({beta} = 0.731, p < .001). The sex-specific pattern of improvement also differed between event categories (era x event type x sex interaction, {beta} = 0.786, p < .001): road-running improvements were greater in women than men (4.51% vs 2.62%), whereas throwing improvements did not differ by sex (0.93% vs 1.14%). These findings suggest that AFT benefits women more than men in competition, whether through a greater physiological response or more effective translation of economy gains to race performance, and suggest current laboratory protocols may be insufficiently sensitive to detect potential sex-specific effects.

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Recovery Trends Show Greater Quadriceps Weakness After Patellar Tendon Versus Hamstring Autografts in ACL Reconstruction

Wilebski, B.; Bond, C. W.; Noonan, B. C.

2026-06-10 sports medicine 10.64898/2026.06.08.26355177 medRxiv
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Context: Although knee extensor and flexor strength deficits are well-documented after anterior cruciate ligament reconstruction, limited data exist characterizing how strength recovery evolves over time. Understanding the temporal patterns of recovery, and how they differ by autograft type, is critical for optimizing rehabilitation and return-to-sport decision-making. Objective: To characterize temporal trends in knee extensor and flexor strength recovery during the first year post-ACLR and evaluate differences between patellar tendon and hamstring tendon autografts. Design: Case series. Setting: Sports physical therapy clinics within a large health system. Participants: Five hundred three patients (17.8 {+/-} 3.0 y) who underwent primary reconstruction with either patellar tendon or hamstring tendon autografts and completed a combined 730 return-to-sport tests within 12 months postoperatively. Main Outcome Measures: Normalized peak isokinetic concentric knee extension and flexion torques for involved and uninvolved limbs, and normalized symmetry indices for knee extension and flexion strength. Results: Knee extension strength on both limbs and extension strength symmetry improved over time. Patients with hamstring autografts demonstrated superior involved leg knee extension strength and better extension strength symmetry compared with those receiving patellar tendon autografts, although uninvolved leg strength was similar between autografts. Knee flexion strength on both limbs and flexion strength symmetry also improved over time. Patellar tendon autograft patients exhibited greater strength symmetry, despite no between autografts for flexion strength for the involved or uninvolved limb. Conclusions: Autograft significantly influences muscle strength recovery following anterior cruciate ligament reconstruction. Hamstring tendon autografts are associated with superior recovery of knee extension strength and strength symmetry compared to patellar tendon autografts. These findings underscore the need for graft-specific rehabilitation strategies and earlier identification of patients at risk for delayed recovery.

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Data-driven calibration of low-cost wearable motion trackers for gait and dynamic stability measurement

He, Y.; Dong, Y.; Brodie, M. A.; Kim, J.; Lord, S. R.; Okubo, Y.

2026-07-15 sports medicine 10.64898/2026.07.13.26357919 medRxiv
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Low cost inside out wearable trackers can be deployed at scale to measure body motion, but errors in estimated sensor position propagate through coordinate transformations into derived gait and dynamic-stability metrics. Healthy adults walked on a treadmill at 0.5 to 2.0 m/s while VIVE Ultimate Tracker (VUT) and Vicon data were recorded. Data-driven calibration models were developed to correct tracker coordinates and to estimate full body centre of mass (CoM) from a sacrum-only configuration. Agreement with Vicon was assessed using RMSE, mixed-effects Bland-Altman limits of agreement, MAE, and intraclass correlation coefficients. Calibration improved coordinate-level agreement. For gait parameters, model-corrected VUT showed small errors against Vicon (MAE: 0.24 to 0.71 mm step height, 1.73 to 4.63 mm step length, 0.15 to 0.95 mm step width, 0.26 to 0.88 mm foot clearance). Proxy CoM-derived margin of stability (MoS) agreed excellently with Vicon. For the sacrum-only pipeline, calibration reduced CoM RMSE from 103.65 to 104.04 mm to 7.55 to 8.95 mm, and markedly reduced systematic error in stability outcomes, with extrapolated CoM bias decreasing from 172.92 to 0.29 mm and MoS bias from -75.09 to -3.54 mm. Data-driven calibration improved the measurement utility of low-cost VUTs, enabling inexpensive, relatively simple gait and stability measurement from a sacrum-only setup in controlled settings.

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Which brain injury metrics are suitable for supporting sports head injury assessment? A multi-sport brain strain evaluation

Chan, E. Y. K.; Koumantou, E.; Low, L.; Siy, I.; Jones, C. M.; Austin, K.; Loosemore, M.; McDonald, S. J.; Ghajari, M.

2026-07-02 sports medicine 10.64898/2026.06.30.26356946 medRxiv
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Objective: To identify brain injury metrics suitable for supporting sports head injury assessment by evaluating their association with brain tissue strain and consistency across sports. Methods: Head kinematics from 3,139 impacts in boxing, mixed martial arts, and rugby matches were recorded using instrumented mouthguards and used to calculate nine brain injury metrics. Impacts were simulated using an anatomically detailed finite element brain model to estimate peak 95th-percentile maximum principal strain (MPS) in the brain and brainstem, a measure of tissue deformation associated with long-term pathology. Sport-specific ordinary least squares models estimated xE, the metric value equivalent to a reference MPS of 0.21. Metric-MPS correlations and xE uncertainties were quantified using 5000 bootstrap resamples. Cross-sport consistency was assessed using the coefficient of variation (CV) of sport-specific median xE values, and uncertainty using the normalised confidence interval size (NCIS). Results: XGB, an extreme gradient boosting strain-prediction model, showed the strongest and most consistent correlations with whole-brain (r=0.924-0.974) and brainstem MPS (r=0.887-0.954) across all sports. PRV, BrIC and UBrIC also correlated strongly with whole-brain (r=0.724-0.930) and brainstem MPS (r=0.739-0.900), whereas HIC15 and HARM showed weaker correlation with MPS, particularly in rugby. XGB showed the lowest cross-sport variability (CV=0.034) and uncertainty (median NCIS=0.056). HARM, DAMAGE and HIC15 showed the greatest sport dependence (CV=0.575-0.588) and uncertainty (median NCIS=0.331-0.791). Conclusions: XGB, BrIC, and UBrIC demonstrated the strongest associations with brain tissue strain and the greatest consistency across sports. This study provides a biomechanically informed framework for selecting suitable metrics for sports HIA protocols.